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Hey everyone is Sarah Chris Turner sorry and calm and in this video I'm going to be going over chronic kidney disease also known as chronic renal failure and this video is part of an inkless review series over the renal system and as always don't forget to take a free quiz that you can access at the end of this video so let's get started first let's start out talking about what is chronic kidney disease it is where you have a significant decrease in renal function and this happens over a long period of time and it is irreversible now that is the complete opposite of whenever we talked about in the previous lecture are about acute kidney injury remember that was a sudden decrease in renal function and it tends to be reversible if they can figure out the cause and treat it appropriately now let's look at our kidney and we're going to look specifically at the nephron because whenever we're talking about a decrease in renal function we're really talking about this glomerulus and how it is filtering specifically the glomerular filtration rate or GFR so we'll be using that term a lot GFR because if you can understand the GFR everything else tends to make sense okay so the kidney the functional unit of your kidney that actually produces urine are the nephron and in each can you have millions of these nephrons and the whole goal is to filter our blood that are received from the heart and the glomerulus is the structure that does that so it filters all these substances such as water ions which are like your electrolyzed 5-card things like that urea and creatinine which are waste products and remember urea is a waste product from protein right down in the liver and creatinine is a waste product from the breakdown of muscles so it filters back now the glomerulus does not filter proteins and blood cells you should not find that in your filtrate unless your glomerulus is messed up in here your long barrel is mess up so we can probably expect to find an address down into Bowman's capsule and then it's going to go down through the renal tubules in the renal tubules our innocence what they're going to do is they're just going to tweak that filtrate because the filtrate was created by the glomerulus and it's going to take what the body needs to maintain homeostasis so it's going to reabsorb the amounts of water you need it's going to reabsorb a little bit of urea and it's going to reabsorb our electrolytes that we need however it is not going to reabsorb creatinine so let's talk about creatinine for a second so creatinine is that waste product and it's fully filtered by that Vomero is from the blood stream and it's not going to be reabsorb in that renal tubules so that's why we care so much about creatinine when we.