Hello, welcome to the Chronic Kidney Disease program at the University of California San Diego. My name is Dan, with Sabine Scott, and I'm a nephrologist in our clinic. In this module, we are going to talk about the different stages of Chronic Kidney Disease. Chronic Kidney Disease is quite common; it affects 11% of the U.S. population, which translates to about 30 million people. Another 30 million people are at risk for developing CKD at some point in their lives. Ideally, we would like to prevent individuals from developing CKD in the first place, but unfortunately, that is not always possible. Early detection is the second-best option in order to take appropriate actions to slow down the decline of kidney function. Let's talk about estimating kidney function. It's usually not as precise or easy as checking your weight or even measuring electrolyte levels in your blood. Doctors, nurses, and pharmacists use special equations to estimate kidney function based on the level of creatinine in the blood. What is creatinine? Well, creatinine is a waste product generated by muscle metabolism and removed or excreted, if you will, from the body by kidneys. The higher the creatinine level in the blood, the less efficient kidneys are at removing it from the body. So, the worse the level of kidney function is. The term for the level of kidney function is Glomerular Filtration Rate or GFR. GFR is the rate at which kidneys filter toxins from the blood. This number also correlates with overall kidney function. We stage kidney disease or assign severity based on the GFR. It is extremely important that you know your GFR. In simple terms, you can think of GFR as a percentage of normal kidney function. For example, GFR 40 means that your overall kidney function, yes for both kidneys, is about 40%...
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This is a complex disease that requires a cautious approach to management. Treatment is aimed at lowering the underlying disease and preventing further decline … — Mayo Clinic End Stage Renal Disease — Mayo Clinic Oct 12, 2025 — In the case of end stage renal disease, the end stage includes renal failure, loss of consciousness, a rise in blood pressure that causes increase in fluid in the blood caused by the blood accumulating in the lower limb of the body, and an inability to eat, speak, or move. In the case of end stage renal disease, the end stage includes renal failure, loss of consciousness, a rise in blood pressure that causes increase in fluid in the blood caused by the blood accumulating in the lower limb of the body, and an inability to eat, speak, or move. In the end Stage Renal disease is a collection of more than 20 medical and physiological conditions that results in chronic inflammation of the body. Renal failure is the second major end point in end stage renal disease that occurs when the kidneys cannot process enough fluid to maintain a normal pH and maintain the body's functions. — Mayo Clinic A patient is at increasing risk when there is increased pressure inside the heart (atrial pressure). This can have many causes including diabetes or metabolic disease. If untreated, an enlarged heart could result in a dangerous heart attack.” — Mayo Clinic If you develop blood in the urine, or if you're in the hospital. Your doctor will discuss a different treatment for you.
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